Synopsis of Bernhard Wolfrum’s upcoming presentation at the NTT Research Upgrade 2021 Summit on September 20-21, 2021. To register for the NTT Research Upgrade 2021 Summit, click here.

Transformable 3D Neuroelectronic Interfaces                                                         

Functional interfaces with nervous tissue are a prerequisite for reading out neural activity and implementing neuromodulation strategies for medical or general bioelectronic applications. For example, feedback loops allow the control of organ function, such as muscle activity, via adaptive nerve stimulation in response to a specific biomarker. Requirements on the design of a neuroelectronic interface depend on the targeted functionality and further constraints such as the intended application duration, invasiveness, or specificity. Ideally, design features are adapted based on geometrical requirements calling for transformable neurointerfaces.

Here, we will present strategies for interfacing nerve cells on different spatial scales in vitro and in vivo. We will introduce 3D neuroelectronic interfaces and transformable devices that facilitate straightforward and flexible integration with small peripheral nerves in vivo. We will also discuss the fabrication of devices for electrochemically monitoring neurotransmitter release in addition to electrical neurophysiological signals. Specifically, we will introduce redox cycling concepts for chip-based detection of neurotransmitter fluctuations making use of repetitive oxidation and reduction of target molecules at independently biased and closely-spaced electrodes.